Anjana D. Saxena

Assistant Professor
Biology

Location: 416 Ingersoll Hall Extension
Phone: 718.951.5000 x2671
Fax: 718.951.4659
Email:

We study nucleolar stress factors (NSFs) and their role/s in regulating cell cycle under normal conditions and during cellular responses to DNA damage. Nucleolin is an abundant nucleolar phosphoprotein that is overexpressed in variety of cancers. We study how nucleolin regulates mRNA stability/translation via direct binding to target-mRNAs or indirectly through protein-protein interactions in the p53 signaling, DNA damage response and ribosomal biogenesis pathways. Our long-term goal is to define the role/s of nucleolin in regulating gene expression that drives cellular decisions of growth (hence, survival and proliferation) or cell cycle arrest (that can lead to repair or cell death) with the potential to identify molecules of therapeutic values.

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